Criteria for Therapeutic Drug Monitoring - all global updates

Criteria for Therapeutic Drug Monitoring

·         The drug in question has a narrow therapeutic range, eg: Lithium, phenytoin, and digoxin

·         A direct relationship exists between the drug or drug metabolite levels in plasma and the pharmacological or toxic effects,

·         The therapeutic effect can not be readily assessed by the clinical observation,

·         Large individual variability in steady state plasma concentration exits at any given dose

·         Appropriate analytic techniques are available to determine the drug and metabolite levels

·         Drugs for which relationship between dose and plasma concentration is unpredictable, e.g Phenytoin

·         Non compliance

·         Therapeutic failure

·         Major organ failure

·         Prevention of adverse drug effects


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